vitamin

Riboflavin (Vitamin B2)

Riboflavin (also known as vitamin B2) is one of the B vitamins, which are all water soluble. The conversion of the amino acid tryptophan to niacin (sometimes referred to as vitamin B3) requires FAD. Riboflavin is yellow and naturally fluorescent when exposed to ultraviolet light. In people who eat meat and dairy products, these foods contribute a substantial proportion of riboflavin in the diet. Vegans and those who consume little milk in developed countries are also at risk of riboflavin inadequacy. Exercise produces stress in the metabolic pathways that use riboflavin. Riboflavin deficiency during pregnancy, for example, can increase the risk of preeclampsia. Anemia and cataracts can develop if riboflavin deficiency is severe and prolonged. The earlier changes associated with riboflavin deficiency are easily reversed. However, riboflavin supplements rarely reverse later anatomical changes (such as formation of cataracts).

Where to get it

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Research & evidence

Strong support Some support Weak or no supportColours show how well the sources back each point. The reason is next to each one.

NIH ODS says riboflavin intakes during pregnancy have a positive association with infant birth weight and length. However, maternal riboflavin intake has no association with the risk of orofacial clefts in infants.

Limited evidenceSome support. Shown only in certain groups, uses, strains or doses

Study details

NIH ODS: “Riboflavin intakes during pregnancy have a positive association with infant birth weight and length.” NIH ODS: “However, maternal riboflavin intake has no association with the risk of orofacial clefts in infants.”

Dosage

FormAmount
Any formNo standard dose is listed by our sources.
Dosage varies by body weight, age, sex, existing health conditions, current medications, and pregnancy/breastfeeding status. The amounts above reflect commonly studied or commonly recommended amounts, not a personal prescription. Always consult a healthcare provider before starting a new supplement, especially if you are pregnant, breastfeeding, managing a chronic condition, or taking medication.

Side effects

Well documented Reported (case reports, anecdotal or one study) None reportedThe circle shows how well documented an effect is, not how serious it is. A rarely reported effect can still be serious, so always read ‘When to stop’.

EffectFrequencyWhen to stop
Bright yellow or orange urineWell documentedListed plainly by NIH, MSK or LiverToxVery common at supplemental dosesNot a reason to stop — this is harmless and expected.

Safety & interactions

Safety

NIH ODS says riboflavin is not known to have any clinically relevant interactions with medications.

Contraindications

Drug interactions

GeneralNone listed

NIH ODS riboflavin fact sheet lists no drug interactions. Talk with your healthcare provider before taking riboflavin supplements if you take any medication.

Related

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