Riboflavin (Vitamin B2)
Riboflavin (also known as vitamin B2) is one of the B vitamins, which are all water soluble. The conversion of the amino acid tryptophan to niacin (sometimes referred to as vitamin B3) requires FAD. Riboflavin is yellow and naturally fluorescent when exposed to ultraviolet light. In people who eat meat and dairy products, these foods contribute a substantial proportion of riboflavin in the diet. Vegans and those who consume little milk in developed countries are also at risk of riboflavin inadequacy. Exercise produces stress in the metabolic pathways that use riboflavin. Riboflavin deficiency during pregnancy, for example, can increase the risk of preeclampsia. Anemia and cataracts can develop if riboflavin deficiency is severe and prolonged. The earlier changes associated with riboflavin deficiency are easily reversed. However, riboflavin supplements rarely reverse later anatomical changes (such as formation of cataracts).
Where to get it
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Active compounds & mechanisms
Key compounds:
Research & evidence
Strong support Some support Weak or no supportColours show how well the sources back each point. The reason is next to each one.
NIH ODS says riboflavin intakes during pregnancy have a positive association with infant birth weight and length. However, maternal riboflavin intake has no association with the risk of orofacial clefts in infants.
Limited evidenceSome support. Shown only in certain groups, uses, strains or doses
Study details
NIH ODS: “Riboflavin intakes during pregnancy have a positive association with infant birth weight and length.” NIH ODS: “However, maternal riboflavin intake has no association with the risk of orofacial clefts in infants.”
Source: NIH ODS, Riboflavin — Health Professional Fact Sheet (Updated May 11, 2022), Groups at Risk of Riboflavin Inadequacy View source
Dosage
| Form | Amount |
|---|---|
| Any form | No standard dose is listed by our sources. |
Side effects
Well documented Reported (case reports, anecdotal or one study) None reportedThe circle shows how well documented an effect is, not how serious it is. A rarely reported effect can still be serious, so always read ‘When to stop’.
| Effect | Frequency | When to stop |
|---|---|---|
| Bright yellow or orange urineWell documentedListed plainly by NIH, MSK or LiverTox | Very common at supplemental doses | Not a reason to stop — this is harmless and expected. |
Safety & interactions
Safety
NIH ODS says riboflavin is not known to have any clinically relevant interactions with medications.
Contraindications
Drug interactions
NIH ODS riboflavin fact sheet lists no drug interactions. Talk with your healthcare provider before taking riboflavin supplements if you take any medication.
Related
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